Patent 2017204157

MULTIPLEXED DETECTION WITH ISOTOPE-CODED REPORTERS

Abstract

ABSTRACT Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography tandem mass spectrometry (LC MS/MS). Some aspects of this invention provide affinity reagents encoded with mass reporters for the sensitive and quantitative translation of an analyte of interest into a mass tag. The reagents and methods provided herein have general utility in analyte detection and encoding, for example, in biomolecular profiling, molecular diagnostics, and biochemical encoding. See Fig la and lb. WO 2012/125808 PCT/US2012/029200 1/34 00 CLIN N a~ ue ------- L L£ --- - - - - - - - - - - - - - - - - CTTI'TP TT CAT TP Il)TTT WO 2012/125808 PCT/US2012/029200 2/34 CD co co N co N co co coc coc - C cco co cco co co co (0 LO co co 0 LL suno:'Aj~uecu CA 7TJ C 'P PT FT ClT T' 7 ' fl) Tl T7"1 1

Information

Australian application number
2017204157
Country
US
Status
Filed
Type
Standard
Applicant
Massachusetts Institute of Technology, (US)
Application year
2017

International Patent Classification (IPC) codes

Links

ID Relationship
2012229103 Divisional parent